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Show Notes:

[00:02:35] – (First Question) – Lux Capital and the kind of investments they have made over the years

[00:05:42] – The formation of the investment philosophy for Lux

[00:08:17] – Why randomness and optionality are important cornerstones to the philosophy

[00:09:52] – Investment philosophy 100-0-100 (ambition, arrogance, intellectual humility)

[00:10:40] – How Josh manages his time and attention

[00:12:53] – Investing in Biofuels or Biofools?

[00:13:29] – Obsession with nuclear

[00:15:15] – Investment in metamaterials

[00:18:28] – Focus on autonomous vehicles

[00:21:02] – How all of these gambles are viewed by Josh’s investors

[00:22:56] – Tattoo technology

[00:24:36] – How Josh evaluates people when considering early stage investments

[00:28:10] – Why the minority opinion tends to lead to the best outcomes

[00:29:50] – Memorable experience investing in a founder

[00:30:44] – The idea of thesis-driven approach to private investment

[00:32:38] – Crazy thesis – understanding the emotional needs of our pets

[00:34:59] – Crazy thesis – Turning genetic abnormalities into treatments and cures for common conditions

[00:38:03]– Josh’s learning process through these theses

[00:39:56] – Understanding rebel scientists when it’s impossible to predict what is going to happen

[00:40:03] – new book on CRISPR and gene splicing

[00:44:35] – Can the charge forward mindset be cultivated, or does it have to come naturally

[00:45:49] – Investors that Josh has learned the most from

[00:47:37] – Josh’s comfort investing outside of his usual asset class

[00:50:56] – What is the thinking with the short strategy at Lux

[00:52:31] – SpaceX vs Tesla, good business vs bad business

[00:53:42] – How Josh approaches the quality of a business

[00:55:16] – How does Josh evaluate competitive advantage

[00:56:45] – Where are we in the venture capital landscape

[01:01:42] – How does his outlook on venture capital affect the way Lux is run

[01:02:48] – Thoughts on cryptocurrency

[01:05:28] – An overview of Santa Fe Institute

[01:07:22] – What is the most memorable conversation Josh has ever had

[01:09:34] – What is Josh’s objective function in life

[01:12:43] – Are there people that Josh disagrees with but deeply respects

[01:13:32] – Kindest thing anyone has ever done for Josh